rs2736100
|
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
The results of this study suggested that rs2736100 on TERT-CLPTM1L indicates a poor prognosis for lung cancer in the Chinese Han population.
|
25966219 |
2015 |
rs2736100
|
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
We identified one novel variant at the level corrected for multiple comparisons (rs2741354 in EPHX2 at 8p21.1 with p value = 7.4 × 10(-6)), and confirmed the associations between TERT (rs2736100) and the HLA region and lung cancer risk.
|
23370545 |
2013 |
rs2736100
|
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
Overall, significantly elevated LC risk was associated with rs2736100, rs401681, rs402710, and rs31489 polymorphisms when all studies were pooled into the meta-analysis.
|
24615522 |
2014 |
rs2736100
|
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
The single-nucleotide polymorphisms (SNP) at 5p15 (rs2736100, adjusted odds ratio [aOR] 1.32, 95% confidence interval [CI] 1.03-1.67, P = 0.025; rs402710, aOR 0.82, 95% CI 0.69-0.98, P = 0.025; rs401681, aOR 0.82, 95% CI 0.69-0.98, P = 0.026) and at 15q25 (rs2036534, aOR 0.75, 95% CI 0.61-0.93, P = 0.01; rs6495309, aOR 0.81, 95% CI 0.65-1.00, P = 0.052) were significantly associated with lung cancer risk.
|
22404340 |
2012 |
rs2736100
|
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
We then found that GRSs used as instrumental variables to predict longer telomere length were associated with increased lung cancer risk (OR = 1.51 (95% CI = 1.34-1.69) for upper vs. lower quartile of the weighted GRS, p value = 4.54 × 10(-14) ) even after removing rs2736100 (p value = 4.81 × 10(-3) ), a SNP in the TERT locus robustly associated with lung cancer risk in prior association studies.
|
25516442 |
2015 |
rs2736100
|
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
In conclusion, this meta-analysis demonstrated that TERT rs2736100</span> polymorphism is a risk factor associated with increased lung cancer susceptibility, particularly for lung adenocarcinoma.
|
24390616 |
2014 |
rs2736100
|
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
TERT polymorphism (rs2736100) might be a genetic susceptibility factor for lung cancer in non-smoking females in China.
|
25037574 |
2014 |
rs2736100
|
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
DQA1*03 and the minor allele for a polymorphism, rs2736100, in TERT, another lung cancer susceptibility locus identified in recent GWASs on Europeans and Americans, were indicated to independently contribute to ADC risk with per allele OR of 1.43 (95% CI = 1.31-1.56, P = 7.8 x 10(-16)).
|
20061363 |
2010 |
rs2736100
|
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
The associations between the 5p15 variants and lung cancer differed by histology; odds ratios for rs2736100 were highest in adenocarcinoma and for rs402710 were highest in adenocarcinoma and squamous cell carcinomas.
|
20548021 |
2010 |
rs2736100
|
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
The combined analyses identified six well-replicated SNPs with independent effects and significant lung cancer associations (P < 5.0 × 10(-8)) located in TP63 (rs4488809 at 3q28, P = 7.2 × 10(-26)), TERT-CLPTM1L (rs465498 and rs2736100 at 5p15.33, P = 1.2 × 10(-20) and P = 1.0 × 10(-27), respectively), MIPEP-TNFRSF19 (rs753955 at 13q12.12, P = 1.5 × 10(-12)) and MTMR3-HORMAD2-LIF (rs17728461 and rs36600 at 22q12.2, P = 1.1 × 10(-11) and P = 6.2 × 10(-13), respectively).
|
21725308 |
2011 |
rs2736100
|
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
After the 2nd stage validation (975 cases versus 1022 controls), the study clarified the association that rs2736100 of the TERT gene conferred the highest significant risk of lung cancer (P=4×10(-3) in the 1st stage association, P=4×10(-4) in the 2nd stage validation, and P=1×10(-5), odds ratio=1.24 in the combined population).
|
23368278 |
2013 |
rs2736100
|
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
A statistically significant association between lung cancer risk and 5p15.33 genotypes was found: rs2736100 (odds ratio = 0.78, 95% confidence interval: 0.63-0.97; P = 0.02), rs4975616 (odds ratio = 0.69, 95% confidence interval: 0.55-0.85; P = 7.95 x 10(-4)), primarily for adenocarcinoma.
|
19955392 |
2010 |
rs2736100
|
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
In addition, the rs2736100 G allele, which we previously have shown to be associated with risk of lung cancer in this cohort, was significantly associated with longer telomere length in these same study subjects (P trend = 0.030).
|
23555636 |
2013 |
rs2736100
|
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
This meta-analysis suggests that rs2736100 is associated with the risk of lung cancer.
|
24283584 |
2013 |
rs2736100
|
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
Recent studies have also linked rs2736100 with a longer telomere length and lung cancer risk.
|
26554909 |
2015 |
rs2736100
|
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
This meta-analysis suggested that TERT rs2736100 polymorphism was a risk factor for LC.
|
24535778 |
2014 |
rs2736100
|
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
For lung cancer, which was the most studied tumor type, the estimated joint population attributable risk for three polymorphisms (TERT rs2736100, intergenic rs4635969, and CLPTM1L rs402710) was 41%.
|
22523397 |
2012 |
rs2736100
|
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
These data provide further evidence supporting a role for genetic susceptibility of TERT rs2736100 in the development of lung cancer.
|
24590268 |
2014 |